Mycophenolate mofetil (MMF) in the treatment of epidermolysis bullosa acquisita (EBA) long-term follow-up
نویسنده
چکیده
E pidermolysis bullosa acquisita (EBA) is an autoimmune mucocutaneous blistering disease. Cutaneous involvement presents with blisters primarily on trauma-prone areas healing with milia. Mucosal involvement can lead to irreversible scarring. The treatment of EBA is based on anecdotal reports in the literature with systemic therapies. Mycophenolate mofetil (MMF) is an immunesuppressing agent that has been reported to be effective in the treatment of autoimmune mucocutaneous blistering diseases. This report describes the successful treatment of 4 patients with EBA using MMF as a steroid-sparing agent at our center along with a long term follow-up.
منابع مشابه
Clinical communication — Kliniese mededeling Steroid-sparing effect of mycophenolate mofetil in the treatment of a subepidermal blistering autoimmune disease in a dog
INTRODUCTION Bullous skin diseases are characterised by the formation of clefts, leading to vesicles or bullae. Separation most commonly occurs between the dermis and epidermis and results from loss of structural integrity of the basement membrane zone. Subepidermal bullous diseases (SEBD) have been described mostly in the dog. Although their clinical presentation is variable, it is not possibl...
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Type VII collagen is an adhesion molecule of the extracellular matrix in epithelial basement membranes, and the main constituent of anchoring fibrils at the dermal-epidermal junction (DEJ). Autoimmunity against this protein is causing the rare organ-specific epidermolysis bullosa acquisita (EBA). EBA is a rare acquired, heterogeneous, chronic blistering disease of skin disease of skin and mucou...
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